Professional Cleanroom Cleaning Services
Precision cleaning solutions for controlled environments. Our trained technicians follow ISO and GMP protocols to support your cleanroom’s compliance, sterility, and performance across all critical areas.
Cleanroom Cleaning You Can Count On
Skyline Building Services provides specialized cleaning services for ISO-classified cleanrooms and controlled environments. From pharmaceutical compounding to semiconductor labs, we help maintain the strict cleanliness levels your operation depends on.
Our cleanroom technicians are trained in aseptic procedures, contamination control, and cleanroom gowning protocols. We use ISO-approved cleaning materials and equipment, ensuring particle count control, proper surface disinfection, and regulatory documentation every step of the way.
Our Cleanroom Cleaning Process
We begin with an on-site evaluation of your cleanroom’s classification, SOPs, and compliance requirements. Based on your ISO class and industry regulations, we design a cleaning plan that supports particle control, airflow performance, and validated hygiene procedures.
Our process includes:
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Unidirectional cleaning techniques
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Color-coded and lint-free materials
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Daily, terminal, and pre-audit cleaning
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Full documentation and log sheets
Each team member is trained in gowning, HEPA-safe practices, and contamination prevention.

Cleanroom Services We Provide
We deliver cleaning services for ISO Class 3–8 cleanrooms and controlled environments across multiple industries, including:
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Sterile compounding (USP <797> & <800>)
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Semiconductor and electronics facilities
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Pharmaceutical and biotech manufacturing
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Research and university laboratories
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Aerospace component rooms
Service types include routine cleaning, terminal cleaning, HEPA surface wiping, equipment disinfection, floor maintenance, and wall/ceiling cleaning.
Why Choose Us for Cleanroom Cleaning
What makes your cleanroom services different?
We specialize in high-compliance environments and follow ISO, GMP, and SOP-specific guidelines with full documentation and technician training.
How do you ensure cleanroom safety?
Our team uses lint-free, non-shedding materials, EPA-registered disinfectants, and zone-specific cleaning tools. We follow unidirectional flow techniques and gowning protocols to avoid contamination.
Are your services audit-ready?
Yes — we maintain logs, checklists, and process records to support internal QA reviews and third-party audits with confidence.
Areas We Serve
Providing professional services across three states



Pennsylvania
We are proud to offer commercial cleaning services for businesses in Pennsylvania.
Learn MoreProfessional Commercial Cleaning Services
Get a free, no-obligation quote for your commercial cleaning needs. Our expert team is ready to provide top-quality service for your facility.
Why Choose Us?
We provide reliable, professional cleaning services with a focus on quality and customer satisfaction. Our experienced team uses industry-leading practices to ensure your facility stays clean and safe.